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Seretide 50/250 Accuhaler
Seretide is prescribed for the long-term management of asthma when combination therapy (a long-acting β₂-agonist and an inhaled corticosteroid) is appropriate. It is recommended for:
- Patients who are not adequately controlled with an inhaled corticosteroid and an as-needed short-acting β₂-agonist.
- Patients already stabilized on both an inhaled corticosteroid and a long-acting β₂-agonist.
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✅ Description:
Seretide contains two active components:
- Salmeterol Xinafoate: A long-acting β₂-agonist that helps in the management of asthma and other airway obstructions. It binds to β₂-receptors and provides bronchodilation for up to 12 hours.
- Fluticasone Propionate: A corticosteroid with potent glucocorticoid effects. It reduces airway inflammation and prevents asthma exacerbations, providing symptom relief without significant systemic side effects.
By combining these two medications, Seretide improves lung function, reduces symptoms, and lowers the risk of severe asthma attacks, offering a convenient regimen for patients requiring both treatments.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Asthma
- Chronic obstructive pulmonary disease
✔️ Dosage & Administration
Inhalation Aerosol (Inhaler)
Adults & Adolescents (12+ years):
- 2 puffs of either:
- 25 µg Salmeterol + 50 µg Fluticasone Propionate
- 25 µg Salmeterol + 125 µg Fluticasone Propionate
- 25 µg Salmeterol + 250 µg Fluticasone Propionate
- Taken twice daily
Children (4-12 years):
- 2 puffs of 25 µg Salmeterol + 50 µg Fluticasone Propionate
- Taken twice daily
Inhalation Powder (Capsule Form, for Asthma & COPD)
Adults & Adolescents (12+ years):
- Salmeterol 50 µg + Fluticasone 100 µg or
- Salmeterol 50 µg + Fluticasone 250 µg
- Twice daily (morning and evening, ~12 hours apart)
- Maximum dose: Salmeterol 50 µg + Fluticasone 500 µg twice daily
Children (4-11 years):
- Salmeterol 50 µg + Fluticasone 100 µg
- Twice daily (morning and evening)
For COPD (Adults only):
- Salmeterol 50 µg + Fluticasone 250 µg
- Twice daily (morning and evening)
✅ Important Note: Rinse the mouth after each use to prevent oral infections like thrush.
✔️ Side Effects
The side effects may arise from either Salmeterol or Fluticasone:
Salmeterol-related Side Effects
- Tremors
- Palpitations
- Headache
- Cardiac arrhythmia (atrial fibrillation, tachycardia)
- Muscle cramps
- Oropharyngeal irritation
- Hypersensitivity reactions (rash, swelling, angioedema)
Fluticasone-related Side Effects
- Hoarseness
- Oral thrush (candidiasis)
- Skin hypersensitivity reactions
- Rare cases of facial swelling or throat edema
📌 Preventing Side Effects: Rinse the mouth with water after each inhalation.
✔️ Proper Use of Inhaler
- Shake the inhaler well before each use (at least six times).
- If not used for a week or longer, test spray one puff into the air before use.
- Exhale fully before placing the inhaler in the mouth.
- Inhale deeply & slowly while pressing the canister.
- Hold breath for 10 seconds, then exhale.
- Wait 1 minute between puffs if taking multiple doses.
- Rinse mouth after use to prevent side effects.
📌 Cleaning Instructions:
- Clean the inhaler at least once a week.
- Remove the canister and rinse the plastic actuator under warm water.
- Dry it completely before reassembling.
✔️ Drug Interactions
- Avoid β-blockers (both selective & non-selective), as they may interfere with the effectiveness of Seretide.
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase systemic exposure to Fluticasone Propionate.
✔️ Contraindications
Patients with known hypersensitivity to any component of Seretide.
✔️ Use During Pregnancy & Lactation
- Only recommended if the benefits outweigh potential risks to the fetus or child.
- There is insufficient human data on its safety during pregnancy or lactation.
✔️ Precautions & Warnings
- Consider additional corticosteroid therapy if an infection is present.
- Caution in tuberculosis (active or latent).
- Use cautiously in patients with thyroid disorders (thyrotoxicosis).
✔️ Storage Instructions
- Store below 30°C.
- Keep away from heat, sunlight, and moisture.
- Do not puncture, break, or incinerate the canister.
- Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
